Chronic Myelogenous Leukemia in blast crisis can manifest as either myeloid (more common) or lymphoid blast crisis.Most lymphoblastic crises are of B-cell lineage.T-cell blast crisis is extremely rare, with only a few reported cases.We present a case of a middle-aged man who was diagnosed with CML on peripheral blood and bone marrow biopsy.Because

Hepatitis B virus (HBV) replication is controlled by four promoters (preS1, preS2, Cp, and Xp) and two enhancers (EnhI and EnhII).EnhII stimulates Cp activity to regulate the transcriptions of precore, core, polymerase, and pregenomic RNAs, and therefore, EnhII/Cp is essential for the regulation of HBV replication.This study revealed a distinct mec

A 21-year-old man underwent wedge resection for treatment of pneumothorax.This patient had been diagnosed with Charcot-Marie-Tooth disease (CMTD) and had a history of surgical treatment of scoliosis, pneumothorax, foot deformity, and arm dislocation.Additionally, the patient showed signs of muscle weakness and atrophy in the flexcon reverse osmosis

Background: The global incidence of neurological diseases has been on the rise, creating an urgent need for a validated marker.Neurofilament welding sweater Light Chain (NfL) holds promise as such a marker and has garnered significant attention in the field of neurological diseases over the past decades.Methods: Corresponding articles from 2013 to

Robert J van read more MarumGeriatric Department, University Medical Center Utrecht, Utrecht, The NetherlandsAbstract: Memantine is a low to moderate affinity N-methyl-D-aspartate receptor (NMDAR) antagonist.The effects of memantine in Alzheimer’s disease (AD) have been studied in 7 randomized controlled trials in many post-hoc analyses.T